MMRV (Measles, Mumps, Rubella and Varivax) Vaccine

MMRV is a combination vaccine that protects against measles, mumps, rubella and varicella (chickenpox).  This vaccine became available in 2005 as an option to provide one less shot to children. 

The first dose of MMRV vaccine has been associated with rash and higher rates of fever than MMR and varicella vaccines given separately. Rash has been reported in about 1 person in 20 and fever in about 1 person in 5.

Seizures caused by a fever are also reported more often after MMRV. These usually occur 5-12 days after the first dose. Among 12- to 23-month-olds who received their first dose of measles-containing vaccine, fever and seizure were elevated 7 to 10 days after vaccination. Vaccination with MMRV results in 1 additional febrile seizure for every 2300 doses given instead of separate MMR + varicella vaccines.  This risk is less common than febrile seizures linked to colds or respiratory infections, about 5 in 1,000. 

Comprehensive Pediatrics has chosen not to offer the MMRV vaccine.  We will only offer the vaccines as separate injections.